Conversely, dysregulation of autophagy is implicated in numerous diseases: Cancer: Both a tumor suppressor and a survival mechanism for cancer cells
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a conservative change such as a hydrophobic residue to another hydrophobic residue, or a non-conservative change, e.g., a hydrophobic residue to Modifications in the test polypeptide can be introduced by, e.g., error-prone PCR, shuffling, oligonucleotide-directed mutagenesis, assembly PCR, sexual PCR mutagenesis, in vivo mutagenesis, cassette mutagenesis, recursive ensemble mutagenesis, exponential ensemble mutagenesis, site-specific mutagenesis, gene reassembly, gene site saturated mutagenesis (GSSM), synthetic ligation reassembly (SLR) and/or a combination thereof
EFFECT OF KETOGENIC DIET ON THE OXIDATIVE STRESS Mitochondria play a key role in determining cellular energy production through oxidative phosphorylation
As the BHT + AD group, the animals received 3 mg streptozotocin per kg body weight by stereotactic intraventricular injection
