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Many clinical trials have focused on injection of a combination of growth factors, biomimetic materials, and cultured cells with varied success

Notably, mitochondria maintain a distinct pool of GSH that is independent of cytosolic GCL activity

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We expect that in the near future complex in vitro models (such as liver-on-a-chip platforms or three-dimensional (3D) models), will enhance our understanding of mechanisms, reproduce the inter-individual variability and capture multiple organs interactions involved in the systematic pathogenesis of MetALD