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These PL-PUFAs are then oxidized by iron-dependent enzymes as lipoxygenases (LOXs) or the labile iron pool into lipid hydroperoxides (PL-PUFA-OOH) to undergo the Fenton reaction under the presence of ferrous iron to trigger ferroptosis onset (Lee and Gan, 2022

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Methods Trial design and participants This phase 3, randomized, double-blind, placebo-controlled study was conducted at 41 sites across five countries (Canada, Italy, Hungary, Spain and the United States), as described in a previous publication 8 and listed in the Supplementary information