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10.1136/bcr-2019-231582 147

Moreover, postmenopausal women show reduced circadian robustness compared to premenopausal women, with lower amplitude in wrist temperature rhythms, lower average core body temperature during the sleep midopoint, earlier chronotype with a phase advance of approximately 1 hour, and blunted cortisol fluctuations (Gmez-Santos et al., 2016)