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Description

Mitochondria serve a key role in ferroptosis by acting as central regulators of cellular redox balance, iron metabolism, lipid peroxidation and ROS production

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They also coordinate reactions to injury, stress, and infection

Glutathione peroxidase 4 (GPX4) is a key lipid peroxidase that inhibits ferroptosis by catalyzing glutathione (GSH) to eliminate lipid peroxides, thus preventing lipid peroxidation in cell membranes and maintaining membrane stability (Yang and Stockwell, 2016