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Thereafter, it participates in the integrative stress response (ISR) and activates the transcription factor ATF4, which initiates the corresponding gene expression program

Contribution of GTPase activity to LRRK2-associated Parkinsons disease

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Preclinical and clinical studies have demonstrated that bioactive compounds such as polyphenols, alkaloids, terpenoids, saponins, and flavonoids exert beneficial effects on AD-related pathways by reducing oxidative stress, suppressing neuroinflammation, preventing A aggregation, and modulating tau hyperphosphorylation (Liu et al., 2024)