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Moreover, boosting intracellular NAD + levels using anti-CD38 antibody enhanced antitumor properties of hybrid Th1/17 cells through the upregulation of NAD + -SIRT1-FOXO1 axis [123, 124]

Astrocytes in multiple sclerosis

The angiogenic effect of copper has been well-recognized, which is presumed to attribute to the regulation of factors involved in vessel formation and maturation, especially the pro-angiogenic factor, namely vascular endothelial growth factor (VEGF), and its major transcription factor, namely hypoxia-inducible factor-1-alpha (HIF1) [36]