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Other studies indicate that lower serum IGF-1 concentrations are associated with reduced cognitive function, showing a negative correlation with age, disease duration, and modified Rankin Scale [134, 135], yet a positive association with more substantial declines in Minimum Mental State Examination (MMSE) scores, CSF A 1-42 /A 1-40 ratio, and diminishing recall, language fluency, attention, and numeracy function [134, 136]

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Research has demonstrated that glutamate dehydrogenase (GLUD1) is expressed at a high level in lung adenocarcinoma cells, and lysine 503 (K503) has been identified as the primary ubiquitination site of GLUD1

Cellular redox signaling, influenced by fluctuations in ROS, RNS, and antioxidant systems, governs vital functions like cell growth, programmed death, and immune responses [112]

Extensive research has unveiled intricate interactions and mechanisms between the gut and lung infections, encompassing bacterial translocation, short-chain fatty acids, and recognition receptors for pathogen-associated molecular patterns