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Two other studies showed that gp120 activates microglia by TLR2-NF-B signaling, and by the direct binding of p62 and PKC through the IKK/NF-B signaling pathway (Fig

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The escalation ladder commonly looks like this: weeks 1 through 4 at 2mg, weeks 5 through 8 at 4mg, weeks 9 through 12 at 6mg, then continuing at 6 to 8mg for researchers who tolerate the escalation well