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Research has shown that fibrosis regression, even at one stage, can significantly reduce these risks and improve survival outcomes [46]

At a median follow-up of 27 months, both PFS (HR: 0.07, 95% CI: 0.030.17) and time until PSA progression (HR: 0.09, 95% CI: 0.040.2) favored the 177 Lu-PSMA-617 arm: While the LUNAR trial suggests that the addition of neoadjuvant 177 Lu-PSMA to SBRT provides a 10-month gain in median PFS and hormone therapy-free survival with limited toxicity, important questions/limitations remain: What is the long-term benefit with regard to hard endpoints, such as OS

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163 In addition, in a clinical trial that included 91 chronic tinnitus patients without hearing loss, approximately 90% reported reductions in tinnitus loudness and annoyance after wearing hearing aids for three months to one year

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