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RU58841 is designed to be metabolized locally within the skin after topical application, aiming for minimal systemic exposure

Mechanistically, liver injury may result from mitochondrial dysfunction, oxidative stress, or idiosyncratic hypersensitivity reactions

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Induction of testicular ischemia Testicular ischemia in rats was induced by the torsion and detorsion (T/D) of the left testis for 2 h, as described before 33

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