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AATD-1 is typically caused by a single-letter mutation in DNA, making it a good candidate for base editing

Dnmt1, Dnmt3a and Dnmt3b) and the demethylases teneleven translocation (TET) methylcytosine dioxygenase (Tet13), and the methyl-CpG-binding protein 2 (MeCP2)

Addressing this gender bias in clinical trial enrollment is a necessary step in promoting equitable representation and thus improving health outcomes

Its association with various metabolic irregularities, such as the onset of atherosclerosis, high lipid concentration, obesity, and liver lipid accumulation, is widely recognized (81)