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Certainly, early life stressful events such as maternal separation in the rodent, or child abuse/loss of a parent in humans can cause disruption of the HPA axis in this way ( In addition to, or perhaps as a result of, disrupting the HPA axis, the parental influence at this time is also crucial for establishing feeding patterns long-term

However, as a secondary analysis the authors correlated their findings to a previous study (Mller-Levet et al., 2013) to identify potential genes with altered expression and DNA methylation changes following sleep deprivation

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Finally, membrane lipid composition and more importantly the long polyunsaturated fatty acid (PUFA) is playing a key role in ferroptosis sensitivity