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Similarly, bortezomib, a proteasome inhibitor, enhances ROS production, destabilizes mitochondrial membranes, and induces cytochrome c release in lung cancer cells (Ling et al

Mascharak S, Griffin M, Talbott HE, Guo JL, Parker J, Morgan AG, Valencia C, Kuhnert MM, Li DJ, Liang NE, Kratofil RM, Daccache JA, Sidhu I, Davitt MF, Guardino N, Lu JM, Abbas DB, Deleon NMD, Lavin CV, Adem S, Khan A, Chen K, Henn D, Spielman A, Cotterell A, Akras D, Downer M, Tevlin R, Lorenz HP, Gurtner GC, Januszyk M, Naik S, Wan DC, Longaker MT

Consistent with the observed downregulation of multiple inflammation-related pathways, immune cell deconvolution analysis using CIBERSORT revealed that LP-EVs treatment increased the relative abundance of M2 macrophages and Th17 cells while decreasing M1 macrophages (Figure S8), which suggests that the therapeutic potential of LP-EVs may stem from promoting an anti-inflammatory macrophage shift toward the M2 phenotype together with Th17-mediated tissue repair and barrier defense functions [69, 70]

Microglia and astrocytes in the adult rat brain: comparative immunocytochemical analysis demonstrates the efficacy of lipocortin 1 immunoreactivity

Yu S, Zhou Y, Sun Y, Wu S, Xu T, Chang YC, et al