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In dose-response studies, researchers observed a clear separation between the GH-releasing dose-response curve and the cortisol/prolactin curves, providing a wide therapeutic window for selective GH release

To interpret the binding isotope effects quantitatively, we performed ab initio calculations that were then used to calculate binding isotope effects.[75, 81] The C-H bond of a model 5-deoxypyridoxal-Ala imine was incrementally lengthened and held fixed while the geometry of the remaining atoms was optimized

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VDR signaling might also indirectly influence BA signaling by transcriptionally upregulating the BA-metabolizing enzyme CYP3A4 and efflux transporters like MDR1 and MRP2 (109)

Application to nonionic surfactants