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Further increases appeared in the SiNP AGS seed coating treatments in a SiNP dose-dependent manner (935 U SOD g 1 FW in V1S, 1080 U SOD g 1 FW in V2S and V3S, and 1186 U SOD g 1 FW in V4S)

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Studies have shown that using small molecule EP4 antagonists, such as ONO-AE3-208 and AH23848, or silencing the EP4 gene, can significantly reduce the metastatic potential of RCC in preclinical models