why does glutathione make me poop Benefits & Side Effects Bile acid receptor FXR promotes

Drug metabolism involves the chemical biotransformation of parent drugs molecules, commonly through phase I reactions (catalyzed by CYP450 and FMO enzymes) and phase II reactions (involving conjugation reactions driven by UDP-glucuronosyltransferases, sulfotransferases, N-acetyltransferases, glutathione S-transferases and methyltransferases), leading to more hydrophilic, usually inactive compounds, that are more readily excreted from the liver into urine and feces ( Hence, one way to monitor the harmful effects of a xenobiotic on hepatocytes is by examining the intracellular metabolome

AIM Patient

Science 331 , 15591564 (2011)

In epilepsy, P2Y 1 receptor overactivation perturbs intracellular calcium dynamics and increases glutamate release, thereby intensifying seizure activity

2007;120(3):e637-43