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Studies have also shown that disulfiram-copper (DSF-Cu) can inhibit aldehyde dehydrogenase (ALDH), targeting cancer stem cells, and therefore has a synergistic effect on the chemoresistance of tumor stem cells that affect sorafenib treatment outcomes (199)

Suspected adverse drug reactions, including possible metformin-associated B12 deficiency, can be reported via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)