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The released inhibitor not only inhibited the influx of pyruvate into the mitochondria but also effectively blocked the tricarboxylic acid (TCA) cycle, which is fueled by glucose and lactate, thereby disrupting aerobic respiration and alleviating tumor hypoxia (Figure 6B)

Wu YT, Ru ZQ, Peng Y, Fu Z, Jia QY, Kang ZJ

Eur J Appl Physiol 111:749756

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