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Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer

Subsequently, to evaluate the in vivo biodistribution of the NPs, MNNG/HOS tumor-bearing mice were intravenously injected with ICG labeled NPs (ICG@GCMR) and imaged at various time points by an IVIS spectrum system

Key regulatory pathways, including PINK1/Parkin and BNIP3/Nix, are also dysregulated in the diabetic kidney

Therefore, targeting autophagy regulation may represent a potential strategy to interrupt this pathological transformation

The minor G-allele of the DIO3 variant rs945006 was associated with a protective effect against OA development 105