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Other conditions Interestingly, NMN has been shown to effectively promote the expansion of mesenchymal stromal cells (MSCs) both in vitro and in vivo, stimulate the osteogenic transformation of endogenous MSCs, and protect mouse bones from aging- and radiation-induced damage

Conditions such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), Hashimotos thyroiditis, and coeliac disease are commonly associated with symptoms including joint pain, digestive disturbances, and fatigue commonly seen in autoimmune conditions (46)

Prior study showed that deficiency of Sentrin/SUMO-specific protease 2 (SENP2) resulted in hyper-SUMOylation of multiple potassium channels and neuronal hyperexcitability, finally triggering spontaneous seizures and sudden death [78, 79], which suggests that sumoylation is vital for epilepsy

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