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To date, MK-677 has yet to pass Phase II clinical trials and is classified as an Investigational New Drug by the US FDA

( c-d ) Quantification of tumour number ( c ) and tumour size ( d ) in WT and CPT1A iKO mice on CD

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Given the close collaboration between astrocytes and neurons in energy metabolism [135], it is plausible that lactylation, triggered by the accumulation of lactate, may play a supportive role in bolstering neuronal energy metabolism and be a crucial factor in maintaining the metabolic equilibrium necessary for the proper functioning of neural networks

When the same lot number appears consistently across product documentation, the laboratory record is easier to verify and maintain