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Cysteine residues in Keap1 act as sensors for electrophiles and oxidants, and their oxidation leads to the release and subsequent translocation of Nrf2 into the nucleus where it can bind to the ARE4 sequence in the promoter region of genes involved in antioxidant defense (Moinova and Mulcahy 1999)

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MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation

Conclusion: In patients referred for LT, frailty increases the risk of not receiving a LT, waitlist mortality, pre-LT unplanned hospitalization and prolonged ICU LOS at the time of LT

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