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Given the expression of GPX4 in other cancer types, its oncogenic function also highlights its potential as a therapeutic target for cancer treatment

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It is this dynamic that has made measurement of serum ceruloplasmin the primary screening test for Wilsons.16 Ultimately, the excess retained copper in the hepatocytes of Wilsons patients leads to toxic injury to the cell and eventually spillage of copper into the circulation, where it may be deposited in other organs such as the brain, cornea, and kidneys

Tumor volume was calculated using the following equation: (width 2 length)/2

[DOI] [PMC free article] [PubMed] [Google Scholar] 131.Lewis D.F.V