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Research on the role of ferroptosis in mitochondrial function and its effects on AS is limited

Elsevier, Amsterdam, The Netherlands, pp 639667 Baker AF, Adab KN, Raghunand N, Chow H, Stratton SP, Squire SW, Boice M, Pestano LA, Kirkpatrick DL, Dragovich T (2013) A phase IB trial of 24-hour intravenous PX-12, a thioredoxin-1 inhibitor, in patients with advanced gastrointestinal cancers

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Energy metabolism During aging, a series of changes occur in mitochondrial energy metabolism, including decreased ATP production, increased ROS, and imbalance of mitochondrial homeostasis