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doi: 10.1158/0008-5472.CAN-09-0419

Liver regeneration

(Amsterdam, Netherlands: Elsevier) (2021)

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demonstrated that 20-day administration of EF-2001 can prevent colitis-induced depression-like behavior via the MGB axis in mice, which can reduce rectal and hippocampal inflammatory cytokines such as TNF- and IL-6 and facilitate the NF-B p65/XIAP pathway in the hippocampus (Takahashi et al., 2019)