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Use of the arginine-depleting agent pegylated arginine deiminase ADI-PEG20 in GBM can increase nitric oxide (NO) synthesis and produce cytotoxic pernitrite, increasing the sensitivity of tumor cells to ionizing radiation and significantly enhancing the effect of radiotherapy on GBM

234 Infusion Therapies An infusion therapy, which combines high-dose corticosteroids with low-molecular-weight dextran and pentoxifylline (Trental), was first described by German physician Eberhard Stennert in 1979

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