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Another phase II study assessed the safety and efficacy of varying doses of retatrutide, included participants with a BMI of 25 to 50 kg/m 2 and an HbA1c of 7.0% to 10.5% [114]

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For instance, deficiency of Nrf2 in the bone marrow has been shown to aggravate atherosclerosis in LDL receptor-null (LDLR -/- ) mice (Ruotsalainen et al., 2013)

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