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Notably, the Gprc5a -ko mouse lung cancer model exhibits two significant characteristics: the spontaneous development of lung tumors and a persistent state of inflammation

For nucleic acids, typically from about 30 to about lOOg of nucleic acid is injected into a 70 kg patient, more typically, about 50 to 150g of nucleic acid is injected, followed by boosting treatments as appropriate

Biochimica et BiophysicaActa 1802 (2010) 4551

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Taken together, these results suggest that CRIP1 promotes cancer stemlike properties in HCC