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Supplementary Materials The following supporting information can be downloaded at: Author Contributions Conceptualization, J.J., J.-D.J

The inhibition of inflammatory pathways reduces OS and improve neuropathic symptoms in experimental models (Negi et al., 2011a)

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We published our results in a peer-reviewed journal: Effect of high-dose intravenous vitamin C on inflammation in cancer patients Mikirova NA, Casciari JJ, Taylor PR and Rogers AM Journal of Translational Medicine, 2012, 10:189 (Sep 2012) Intravenous ascorbic acid to prevent and treat cancer-associated sepsis