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Production of butyrate by gut commensals contributes to immunity regulation of the host by inducing the differentiation of colonic and systemic regulatory T cells 5,6 and has an important epigenetic effect on gut epithelial cells by inhibiting histone deacetylase (HDAC) 7,8

doi: 10.3892/or.6.6.1191 126 MynottTLLadhamsAScarmatoPEngwerdaCR

Similar to 2-AAPA treatment, knockdown of Glutathione Reductase elevated the GSSG/GSH ratio (Figure S3A) and diminished ER stress signaling (Figure 4A)