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Some are enzymes involved in detoxifying free radicals and include glutathione peroxidases and thioredoxin reductase

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One of the central mechanisms by which tumors achieve this immune evasion is through the induction of IDO1 activity and the subsequent depletion of tryptophan and accumulation of kynurenine ( Figure 1A ) ( Tryptophan depletion alone has significant effects on immune cell function since T cells, particularly effector T cells, are highly sensitive to tryptophan availability