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Berberine, a single bioactive compound derived from several Chinese medicinal herbs, increased hippocampal 5-HT, NE, DA, and BDNF levels in CUMS rats while modulating SCFA metabolism via alterations in Firmicutes, Bacteroidetes, and Lachnospiraceae (Huang M

While this genetic mutation tells us something about how someones body might respond to a certain lifestyle, there is still variance within this group

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Hepatic and Renal Toxicity: Patients should undergo regular liver and kidney function tests due to the risk of severe hepatotoxicity and nephrotoxicity

Additionally, future studies should aim to investigate the roles of caffeine metabolites individually and synergistically, to better understand their contributions to caffeines overall neuroprotective profile