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Buffone MG, Wertheimer EV, Visconti PE, Krapf D

They reported that macrophages exposed to ferrylHb in atherosclerotic plaques exhibited a distinct transcriptomic profile affecting gene expressions associated with inflammation (IL-1 and TNF- et), angiogenesis, tissue remodeling, iron metabolism, apoptosis, PI3K signaling, lipid transport, and calcification, thereby contributing to the transformation of atherosclerotic lesions toward aproatherogenic phenotype (Potor et al., 2021)