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Experimental Studies The administration of theophylline (10 or 20 g/ml) 2 h before human TGF-1 stimulation suppressed TGF--induced type I collagen (COL1) mRNA expression in lung fibroblasts and also inhibited fibroblast proliferation (48)

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Option A: BPC-157 First Sequence: Inject BPC-157, wait 45-60 minutes, then apply cryotherapy Rationale: Allows peptide absorption before cold-induced vasoconstriction reduces blood flow