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For instance, alpha-ketoglutarate (KG), also known as 2-oxoglutarate (2OG), is a co-substrate for KG-dependent dioxygenases (KGDDs) that include DNA and histone demethylases (Islam et al., 2018)

[51] Clostridium kluyveri NAD-dependent 4-hydroxybutyrate dehydrogenase (4hbd) EC 1.1.1.61 Citrobacter freundii and Klebsiella pneumoniae 1,3-propanediol dehydrogenase EC 1.1.1.202 (gene dhaT) Bacillus methanolicus NAD-dependent methanol dehydrogenase EC 1.1.1.244 [52] E