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Visualization of engaged Pol II, mRNA expression and chromatin state The PRO-seq, mRNA-seq, ChIP-seq and DNase I-seq datasets were visualized using an in-house tool (Hojoong Kwak, Cornell University, Ithaca, USA) and Integrative Genomics Viewer (IGV) 73

Later on, the Arabidopsis VTC3 protein was identified by vtc3 mutant shows no increase in AsA content in response to light and heat (Zhang et al., 2012), the tomato SlHZ24 ( Arabidopsis GMP): KONJAC (Sawake et al., 2015) and CSN5B (Wang et al., 2013), the latter being involved in the ubiquitination and subsequent degradation of VTC1

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Motterlini R, et al

However, some cell types are severely impaired by DMSO function