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23 Importantly, compromised epithelial barrier function can amplify a positive-feedback cycle of immune-associated barrier dysfunction, which is closely postulated with both the pathogenesis and the progression of gastrointestinal diseases

They are both optical non-invasive techniques that permit and (biopsy) images without the fixing, sectioning and staining, which are common procedures for histology analysis [54]

The improvements could be due to placebo effect or the invasive procedure itself (cystoscopy), and subtle side effects might have gone unnoticed in such a small sample