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doi: 10.1038/ni1424 14 ZhengWFlavellRA

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The gcn2-atf4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

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P Natl Acad Sci USA 105 , 1704617049, (2008)

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Notably, the increase in incidence of IBD parallels the increase in dietary intake of -6 PUFAs such as AA, which is a major component of a Western diet and contained in meat and eggs 19

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At the cellular level, 3-HK promotes apoptosis by increasing mitochondrial membrane permeability, facilitating cytochrome C release and caspase-dependent cell death accompanied by oxidative damage [139, 154]

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