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Step 2: This is where glutathione really helps

The ESI-MS investigations were conducted in both negative and positive scanning mode enabling detection of both positively and negatively charged GSH and GSSG species, as well as (modified) iron(II) and iron(III) complexes

Moreover, peroxisome proliferator-activated receptor- coactivator-1 (PGC-1) also displays antioxidant defense responses via its role in promoting upregulated expression of antioxidative enzymes, including sod2 (Valle et al., 2005