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In cells exposed to 10 M BSO, a -glutamyl-cysteine ligase (GCL) blocker, mBBr fluorescence was significantly reduced to 51 4% ( n = 11) as compared to untreated cells

Interestingly, crocin strongly inhibited the expression of M2 markers ( Figure 5A ), increased HO-1 and SOD2 expression ( Figures 5C, D ) and decreased NOS2, NOX1 and KEAP1 expression in M2 macrophages ( Figures 5B, D )

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In fact, the role of p53 in the control of ROS levels is controversial, as it may promote both oxidant and antioxidant gene expression