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Another form of XO is xanthine dehydrogenase (XD)

High drug concentrations and repeated instillation are commonly needed to improve the efficacy of drug administration through the local route, which may lead to poor patient compliance and numerous side effects [6]

The reactive species produced in oxidative stress can cause direct damage to the DNA and are therefore mutagenic, and it may also suppress apoptosis and promote proliferation, invasiveness and metastasis