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Abstract Ferroptosis is a form of cell death elicited by an imbalance in intracellular iron concentrations, leading to enhanced lipid peroxidation

For the former, enzymatic pathways as well as ATP presence are exploited as readout to analyse different functions in cells

Nelson DB, Mitchell KG, Wang J, Fujimoto J, Godoy M, Behrens C, Zheng X, Zhang J, Sepesi B, Vaporciyan AA, Hofstetter WL, Mehran RJ, Rice DC, Walsh GL, Swisher SG , Moran CA, Kalhor N, Weissferdt A, Wistuba II, Roth JA, Antonoff MB

Key enzymatic components include SODs, catalase (CAT), glutathione peroxidases (GPx), and peroxiredoxins (PRDXs) (Ighodaro and Akinloye, 2018)

These findings correlated with extensive white matter alterations in cerebrum, cerebellum, mesencephalon and in the upper spinal cord