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doi: 10.3389/fmolb.2024.1403844 Received 20 March 2024 Accepted 24 July 2024 Published 13 August 2024 Volume 11 - 2024 Edited by Michal Ciborowski, Medical University of Bialystok, Poland Reviewed by Tae Jin Lee, Augusta University, United States Peter D

The clearance (L/hr) of APAP increased from 2.02 L/hr at 1 month of age to 4.09 L/hr at 1 year of age to 14.27 L/hr at 16 years of age (based on our own analyses on the published mean values with a Spearman correlation, there is a significant correlation between age and APAP clearance, p G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A Exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure