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Because theyre smaller, they can move around the body more easily and act quickly where needed

Drug Metab Dispos 21:841845 Elfarra AA, Duescher RJ, Hwang IY, Sicuri AR, Nelson JA (1995) Targeting 6-thioguanine to the kidney with S -(guanin-6-yl)-l-cysteine

This feature renders cancer cells more sensitive to external stimuli that further increase the production of ROS 145,146,147 , and, as schematically summarized in Table 1, an increasing number of therapeutic strategies are being developed to elevate ROS levels to overwhelm the redox adaptation of the same cells, inducing oxidative stress incompatible with cellular life 148,149,150,151 (Fig