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The altered autoregulation of blood flow cannot meet the metabolic demand of tissues in ME/CFS, leading to tissue hypoxia and subsequent ischaemia/reperfusion injury with its associated symptoms and signs (29)

2010) irrespective of calcium influx from the extracellular medium

GHK-Cu has documented anxiolytic effects, but relying on a peptide for stress management is insufficient

The human mature peptide consists of two antiparallel -sheets linked by a hairpin loop resulting in an amphipathic peptide [157]

Brain, Behav, & Immun-Health 26:100554 Rouzer SK, Gutierrez J, Larin KV, Miranda RC (2023) Alcohol & cannabinoid co-use: implications for impaired fetal brain development following gestational exposure