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The perturbation in systemic iron homeostasis was attributed to higher systemic absorption of iron due to enhanced efflux from enterocytes through the basolateral transporter, ferroportin 1

AHK-Cu treatment was associated with decreased TGF-beta-1 secretion in dermal fibroblasts

Butyrate acts blocks the IL-6/STAT3/IL-17 and TLR2-MyD88-NF-B pathways, and bidirectionally regulates cytokine secretion, Specifically, it upregulates anti-inflammatory factors such as IL-4 and IL-10 and downregulates pro-inflammatory factors such as CRP, IL-8, IL-12, and TNF- (91, 92)

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The enhanced targeted delivery to the lesion holds considerable potential for augmenting therapeutic efficacy