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After phosphorylation, -arrestin 2 is recruited to the plasma membrane to bind with MOR and prevent the further activation of G protein to realize desensitization [87], accelerating the uncoupling of MOR with G protein, forming receptorprotein complexes (MOR/-arrestin 2/Adaptin-2/Clathrin) at the same time to promote the internalization of MOR until the internalization is suspended by dynamin [21,87,88,89]

Vitamin B 12is essential to growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis

Osimo EF, Pillinger T, Rodriguez IM, Khandaker GM, Pariante CM, Howes OD

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