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Metabolic parameter measurement Respiratory exchange ratio (RER) and energy expenditure (EE) were obtained with open-circuit Oxymax/CLAMS (Columbus Instruments Comprehensive Lab Animal Monitoring system)

Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting

PMID 30231877

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Researchers discovered that the POI model revealed lower ovarian SIRT1 expression, indicating a significant relationship between SIRT1 and ovarian reserve and its possible application as a measure of ovarian aging 21