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while its continuous activation in T cells induces pyroptosis by inhibiting the peroxisome proliferator-activated receptor (PPAR)-nuclear factor erythroid 2-related factor 2 (Nrf2) axis, leading to immunosuppression (54)

Francque S, Verrijken A, Caron S, Prawitt J, Paumelle R, Derudas B, Lefebvre P, Taskinen MR, Van Hul W, Mertens I, Hubens G, Van Marck E, Michielsen P, Van Gaal L, Staels B (2015) PPARalpha gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

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